Protein name:
    E3 ubiquitin-protein ligase HACE1 ;
    
    Alternative:
    
    HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Bovine  (Bos taurus).  
    
 
General Annotation
    Sub Unit:
    Interacts with RARB. Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) and RAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.
    
 
    Function:
    E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Golgi apparatus  
      Golgi stack membrane 
      
     
      Cytoplasm 
      
     
      Endoplasmic reticulum 
      
    A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins. 
  
    
 
    
    Protein Attributes:
    
    50:
    MERAMEQLNR |  LTRSLRRART |  VELPDDNETA |  VYTLMPMVMA |  DQHRSVSELL |  
    
 
    100:
    SNSKFDVNYA |  FGRVKRSLLH |  IAANCGSVEC |  LVLLLKKGAN |  PNYQDISGCT |  
    
 
    150:
    PLHLAARNGQ |  KKCMSKLLEY |  SADVNICNNE |  GLTAIHWLAV |  NGRTELLHDL |  
    
 
    200:
    VQHVSDVDVE |  DAMGQTALHV |  ACQNGHKTTV |  QCLLDSGADI |  NRPNVSGATP |  
    
 
    250:
    LYFACSHGQR |  DTAQILLLRG |  AKYLSDKNGV |  TPLDLCVQGG |  YGETCEVLIQ |  
    
 
    300:
    YHPRLFQTII |  QMTQNEDLRE |  NMLRQVLEHL |  SQQSESQYLK |  ILTSLAEVAT |  
    
 
    350:
    TNGHKLLSIS |  SNYDAQMKSL |  LRIVRIFCHV |  FRIGPSSPSN |  GIDMGYNGNK |  
    
 
    400:
    TPRSQVFKPL |  ELLWHSLDEW |  LVLIATELMK |  NKKDSTDITS |  ILLKQKGQDQ |  
    
 
    450:
    DGTSIPPFEP |  PGPGSYENLS |  TGTGESKPDV |  LGGKQEASAD |  CQDVISMTAN |  
    
 
    500:
    RLSAVIQAFY |  MCCSCQMPPG |  MTSPRFIEFV |  CKHDEVLKCF |  VNRNPKIIFD |  
    
 
    550:
    HFHFLLECPE |  LMSRFMHIIK |  AQPFKDRCEW |  FYEHLHSGQP |  DSDMVHRPVN |  
    
 
    600:
    ENDILLVHRD |  SIFRSSCEVV |  SKANCAKLKQ |  GIAVRFHGEE |  GMGQGVVREW |  
    
 
    650:
    FDILSNEIVN |  PDYALFTQSA |  DGTTFQPNSN |  SSVNPDHLNY |  FRFAGQILGL |  
    
 
    700:
    ALNHRQLVNI |  YFTRSFYKHI |  LGIPVNYQDV |  ASIDPEYAKN |  LQWILDNDIS |  
    
 
    750:
    DLGLELTFSV |  ETDVFGAMEE |  VPLKPGGGSI |  LVTQNNKAEY |  VQLVTELRMT |  
    
 
    800:
    RAIQPQINAF |  LQGFHMFIPP |  SLIQLFDEYE |  LELLLSGMPE |  IDVSDWIKNT |  
    
 
    850:
    EYTSGYERED |  PVIQWFWEVV |  EDITPEERVL |  LLQFVTGSSR |  VPHGGFANIM |  
    
 
    900:
    GGSGLQNFTI |  AAVPYTPNLL |  PTSSTCINML |  KLPEYPSKEI |  LKDRLLVALH |  
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Chicken
         
        
        Mouse
         
        
        Rat
         
        
        Bovine
         
        
     
    
        ELISA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Protein for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Protein for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Protein for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Protein for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
    
        Protein for Bovine E3 ubiquitin-protein ligase HACE1
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Precision
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Recovery
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Linearity
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    
    
    References
    
    
        
            
        
            
                1.
                
                    
                        
                            "A whole-genome assembly of the domestic cow, Bos taurus." 
                        
                        
                            Zimin A.V. 
                        ,
                            
Delcher A.L. 
                        ,
                            
Florea L. 
                        ,
                            
Kelley D.R. 
                        ,
                            
Schatz M.C. 
                        ,
                            
Puiu D. 
                        ,
                            
Hanrahan F. 
                        ,
                            
Pertea G. 
                        ,
                            
Van Tassell C.P. 
                        ,
                            
Sonstegard T.S. 
                        ,
                            
Marcais G. 
                        ,
                            
Roberts M. 
                        ,
                            
Subramanian P. 
                        ,
                            
Yorke J.A. 
                        ,
                            
Salzberg S.L. 
                        
                        
                        
                        
                            Genome Biol.10:R42.01-R42.10(2009)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                    strain :
                    
Hereford .